Invest Ophthalmol Vis Sci. 2005 May;46(5):1742-7.Rah H1, Maggs DJ, Blankenship TN, Narfstrom K, Lyons LA.Author information1Department of Population Health and Reproduction, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA.AbstractPURPOSE: An early-onset retinal degenerative disease has been identified in Persian cats. This study genetically, clinically, and histologically characterized the disease. A breeding colony was established to assist with identification of the causative gene and to provide a resource for vision research.METHODS: Cats were produced from testcross breedings. Kittens underwent serial ophthalmic and neuro-ophthalmic examinations. Globes were harvested from age-matched affected, obligate carrier, and control cats and were evaluated by light microscopy. Fluorescein angiography assessed retinal and choroidal vasculature.RESULTS: Test breedings confirmed an autosomal recessive mode of inheritance. Rate and extent of disease progression were similar among individual affected cats.

The earliest clinical signs (reduced pupillary light reflexes) were seen at 2 to 3 weeks of age. Retinal degeneration was virtually complete by 16 weeks of age. Histologic changes progressed rapidly and paralleled clinical findings. Histologic lesions were limited to the photoreceptors, outer plexiform layer, and retinal pigment epithelium in all but the terminal stages, when subtle changes were noted within the inner nuclear layer.CONCLUSIONS: Characterized in this study was an autosomal recessive, early-onset, retinal degenerative disease in Persian cats that is likely to be more prevalent in this breed than previously suspected. This feline disease model may identify a new gene or provide biological insight into some forms of early-onset retinitis pigmentosa (RP) in humans and genetic retinal degenerations in other species. A breeding colony that will assist in the identification of the causative gene has been established and is available for studies in vision research.PMID: 15851577 DOI: 10.1167/iovs.04-1019 [PubMed - indexed for MEDLINE] MeSH TermsAnimalsAtrophyBreedingCat Diseases/diagnosisCat Diseases/genetics*CatsDisease Models, AnimalDisease ProgressionFemaleFluorescein Angiography/veterinaryGenes, RecessiveMalePedigreeReflex, PupillaryRetina/pathology*Retinal Degeneration/diagnosisRetinal Degeneration/geneticsRetinal Degeneration/veterinary*Full Text SourcesSilverchair Information SystemsOther Literature SourcesCOS Scholar UniverseMiscellaneousOMIA - Online Mendelian Inheritance in Animals: Data: Gene Expression - SciCrunch

To move to another page click on the button or Welcome to Highlandkatz Cattery We are a CFA registered cattery located in Check out the cats and kittens we have "Selkirk 101" for more information about the Selkirk Rex breed. GC BW NW Truebrit Mississippi Blues(of Highlandkatz) - 2013-2014 11th Best Cat - CFA National  2nd Best Cat CFA Region 721st Best Kitten Region 6Most Highly decorated Selkirk in CFA HistoryWall Drapes Hire London Mr Edy kittens   Twist o' the ol' Irish ( Griffin)Corgi Puppies Sale Ma and  Mississippi Gambler  ( Teddy)Kittens For Sale In Nigeria GC BW Highlandkatz Twisted Sister CFA Best Longhair Selkirk 2013-20142nd Best of Breed - Highlandkatz Storm Trooper and a handsome young

man that previously loved this kitty. He is a handsome blue tabby shorthair Selkirk neuter looking for a show home or a home with children. Free Kitten to good home Free! Siamese kittens Only 1 left ! $ — Kitties/ 2 Free Free! free orange male cat Free! Sasha the lap cat $45 Kittens $5 White Cat w/ Black Spots $30 Siamese Adult Feline Free! Looking for my cat $ — Kittens free to good home Free! 1 eyed kitten for adoption $25 kittens Free! 2 male kittens Free! Mr. Peaches free to good home Free! Free baby kittens $ — Cat in Need of Home Free! Perfect barn cat or mouser Free! Looking for a good home Free! $ — next 1 Up to Pets & More Ad Type for sale (59) wanted (1) (0) free (61)Seller private party (110) business (10)Photos required (103)PricePosted last 24 hours last 3 days last 7 daysStatus sold (13)Sort by Latest Popularity Lowest Price Highest Price City [A-Z] Oldest Choose City post Ad in Cats My Location Choose City remember me on this device forgot register help Featured Ads Featured Ads rotate in prominent locations throughout LSN search results.

Click here to add text.Thank you for stopping by and visiting. Bradpurr is a small  cageless cattery in Tennessee. My name is Fran. I have been breeding and showing Himalayan cats for over 25 years. Well, more precisely, Himalayans and household pets. That is how I got started in cats and breeding. I got my first pet, a cat , when I was in my 20's. That led to more cats, of course, and rescues and then to showing my HHP's. During those times of waiting in between rings, I fell in love with the Himalayan cat. And here, I guess you can say, the rest is history. I breed not only for the show standard but with those wide open expressions with huge round eyes. And you will see from the articles within, that healthy cats are paramount. Much attention is placed on optimum nutrition and a chemical free environment. Healthy cats make happy cats. Now in my 60's I have finally allowed myself to pass the showing on to someone else. So, while I will still have my sweet pet kitties, I will now have breeder and show kitties available also.

Please enjoy your visit.Southern Regions Best Himalayan AdultOakheaven's Mewsic Line of Bradpurr"Melody"This site is dedicate to my Melody. My once in a life time kitty. She had my heart from the moment I saw her and still does. I will never forget her. She is the reason I will always love the himalayan cat.We are a small cattery that breeds Munchkins, Napoleons and sometimes a few Persians. Our cats and kittens are raised with lots of love and spoiled rotten. We are lucky to have some of the more rare Munchkin colors such as chocolate, fawn and lilac. If you are interested in a Munchkin, Napoleon or Persian kitten or cat, you’ve come to the right place. Browse through our site to see our breeders, kittens or cats that we have available, some of our kittens in their new home and of course, our policies. If you have any questions, please feel free to contact us. We are a TICA Registered Cattery Kittens from Josie’s munchkins have won prestigious titles from TICA this year !!!